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5 MeV. D is like A, except that each bar is 10 from vertical, reducing orientation contrast to 20. SUSTAINED-RELEASE DRUG DELIVERY Sustained-release drug delivery systems, 8(3), 4238. As for the case of Figure 39. 44), can be established without reference to dAlembert formula, as we will see later. The 6.
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1966, determined on 1204 See the information section on general monographs (cover pages) binary outcome 457 binomial distribution 457 calculus, Bernoulli development carry-over about carry-over 2757 Bayesian approach bioequivalence 378 definition 458 and dose-finding 321 eliminating 27880 periods 280, 283 problem for cross-over trials singlemultidose cross-overs testing for 2778 13 277 2823 early work 13 bioavailability 339, 457 bioequivalent studiestrials 284 457 7575 rule 3778 about bioequivalent studies AUC 3612, 364, 366, 3689 Bayesian approaches and blinding 378 carry-over adjustment 378 confidence intervals 3735 time issues 280 two-stage procedure confidence limits 3725 equivalence limits homoscedasticity 36970 KullbackLeibler (KL) approach log-transformation versus Fiellers theorem 2802 2789 368 and parallel assay 331 power approach 365 prescribability 3701 side effects 363 switchability issues 3712 treatment version problems variability of formulations bioinformatics 433, 447 biometrics 17, 457 biostatistician 457 biostatistics 457 bivariate distribution 31 blinding chance, and n-of-1 trials change-over design 459 chemical markers 166 chi-square testsstatistics Christmas tree boundaries circadian rhythms 354 clearance 339, 353, 357, 459 clinical relevance, and baselines clinical trials about clinical trials 278 analysis and reporting 601 and baseline comparisons 29 bias problems 34 blinded trials 345 blinding 367 comparatorstrategy choice concomitant observations 378 concurrent controls 334 counterfactual argument 289 covariance 38 cross-over trials 34 and data generation models 3941 defining effects 28 discriminatory trials 134 with historical controls 29 history 201 hypothesis testing 489 identifiability 43940 measuring treatment effects 389 in ACES 2423 and allocating treatments and bioequivalence 378 blinded trials 345 cut-off designs 81 dose-finding 326 n-of-1 trials 2923 placebo-controlled trials 367 and treatment allocation 867 un-blinding and sequential trials 310 block 458 Bonferroni approach, sequential trials 298 Bonferroni corrections 1513, 1623 boundary approach, sequential trials 2967, 458 Christmas tree boundaries 297 continuous framework 297 3645 3856, 458 399 236, 36178, 3612 3767 362, 3656, 3624 3701 2878 1001 70 3678 3968 4012 weighting issues case-control studies case series approach causality assessment, single-case cause of effects problems and the counterfactual argument 289 establishment 392 censored valuesinformation 387, 4589 Index 485 17, 252 297 41011 3.
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Acrosomal process A long process actively protruded from the acrosomal region of the spermatozoon following contact with the egg and that assists penetration of the gelatinous capsule. Res.  Thus, heat stability during pasteurization may be a parvovirus-specific trait, which is not due to virus association with cellular membranes.
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