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0 Test solution (b). 706±0. Let us consider a spherical particle of radius R, which we divide into two hemispheres I and II. 627-49. 9 source: Balance of Payment Statistics Yearbook 2004, Washington, DC: International Monetary Fund, 2004. 1 g in dilute hydrochloric acid R and dilute to 10 ml with water R. Several in vitro techniques, such as digitonin treatment of hepatocytes, for estimating unbound drug concentra- tions within hepatocytes have been reported in the literature; however, none of them appears to be reliable because of experimental difficulties andor unrealistic assump- tions.

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